假黄皮茎枝化学成分研究

Chemical Constituents from Stems of Clausena excavata

目的：对假黄皮茎枝的化学成分进行研究。方法：采用硅胶柱色谱、反相中压柱色谱和制备液相色谱等方法进行分离纯化,运用波谱数据并结合文献鉴定结构。结果：从假黄皮茎枝中分离得到了11个化合物,分别鉴定为：adicardin（1）、香豆素-7-O-α-L-鼠李糖基-（1→6）-O-β-D-葡萄糖苷（2）、6-甲氧基-香豆素-7-O-α-L-鼠李糖基-（1→6）-O-β-D-葡萄糖苷（3）、alloisoimperatorin（4）、isopentenoyloxypsoralen（5）、nordentatin（6）、xanthyletin（7）、7-羟基香豆素（8）、3-甲酰基咔唑（9）、3-甲酰基-6-甲氧基咔唑（10）、murrayanine（11）。结论：其中,化合物2-4、10为首次从该植物中分离得到,化合物1和5为首次从该属植物中分离得到。

Objective： To study the chemical constituents from the stems of Clausena excavata. Methods： The constituents were isolated by various chromatographic techniques（ silica gel,RP-MPLC and PHPLC） and their structures were determined on the basis of their spectroscopic data,as well as literatures. Results： Eleven compounds were separated and identified as adicardin（ 1）,7-[O-α-L-rhamnopyranosyl-（ 1→6）-O-β-D-glucopyranosyloxy]coumarin（ 2）,6-methoxy-7-[O-α-L-rhamnopyranosyl-（ 1 →6）-O-β-D-glucopyranosyloxy]coumarin（ 3）,alloisoimperatorin（ 4）,isopentenoyloxypsoralen（ 5）,nordentatin（ 6）,xanthyletin（ 7）,7-hydroxycoumarin（ 8）,3-formylcarbazole（ 9）,3-formyl-6-methoxy carbazole（ 10）,and murrayanine（ 11）. Conclusion： compounds 2 - 4 and 10 are isolated from this plant for the first time,and compounds 1 and 5 are isolated from Clausena genus for the first time.