五味子超临界萃取部位化学成分研究

Chemical Constituents from Supercritical CO_2 Extraction of Schisandra chinensis

目的:对五味子超临界萃取部位进行化学成分研究。方法:采用常规硅胶柱层析、重结晶等方法分离纯化,经核磁、质谱等波谱分析方法鉴定化合物结构。结果:从五味子超临界萃取部位中共分离得到9个化合物,分别鉴定为:大黄酚(1)、五味子乙素(2)、β-谷甾醇(3)、五味子丙素(4)、五味子醇甲(5)、当归酰戈米辛H(6)、胡萝卜苷(7)、柠檬酸二甲酯(8)、莽草酸(9)。结论:其中,化合物1、8、9为首次从五味子中分离得到,化合物1为首次从五味子属植物中分离得到的蒽醌类化合物。

Objective： To study the chemical constituents from the supercritical CO2 extraction of Schisandra chinensis. Methods：The compounds were separated and purified by conventional column chromatography and their structures were identified by spectroscopic methods. Results： Nine compounds were isolated from the supercritical CO2 extraction of Schisandra chinensis,and their structures were identified as chrysophanol（ 1）,schisandrin B（ 2）,β-sitosterol（ 3）,schisandrin C（ 4）,schisandrol A（ 5）,angeloylgomisin H（ 6）,daucosterol（ 7）,1,5-dimethyl citrate（ 8）,and shikimic acid（ 9）. Conclusion： Compounds 1,8 and 9 are isolated from Schisandra chinensis for the first time,and compound 1 as an anthraquinone is isolated from this genus for the first time.