灰毡毛忍冬根化学成分研究

Study on Chemical Constituents from Roots of Lonicera macranthoides

目的：研究灰毡毛忍冬Lonicera macranthoides Hand.-Mazz.根的化学成分。方法：采用多种柱层析分离技术进行分离纯化,根据化合物的波谱数据和理化性质进行结构鉴定。结果：从灰毡毛忍冬根中分离得到7个化合物,分别鉴定为：ribenol（1）、excoecarin C（2）、18-hydroxy-13-epi-manoyloxide（3）、积雪草酸（4）、齐墩果酸（5）、β-谷甾醇（6）、β-胡萝卜苷（7）。结论：其中,化合物1~4为首次从该属植物中分离得到,化合物5为首次从该植物中分离得到,所有化合物均为首次从该植物根中分离得到。

Objective： To study chemical constituents of the roots of Lonicera macranthoides. Methods： The chemical constituents were isolated and purified by means of several chromatographic techniques and their structures were elucidated by spectroscopic methods. Results： Seven compounds were isolated and identified as ribenol（1）,excoecarin C（2）,18-hydroxy-13-epi-manoyloxide（3）,asiatic acid（4）,oleanolic acid（5）,β-sitosterol（6） and β-daucosterol（7）. Conclusion： Compounds 1 ~ 4 are obtained from this genus for the first time. Compound 5 is obtained from this plant for the first time. All the compounds are found from the roots of Lonicera macranthoides for the first time.