氯吡格雷对复方丹参滴丸药动学的影响

Effect of Clopidogrel on Pharmacokinetic of Fufang Danshen Dripping Pill(FDDP)

目的:研究氯吡格雷对复方丹参滴丸中人参皂苷Rg1药动学的影响。方法:SD大鼠20只,随机分为2组:单独给药组(复方丹参滴丸324 mg/kg)、联合用药组(复方丹参滴丸324 mg/kg+氯吡格雷30 mg/kg),连续21d灌胃给药,比较两组间人参皂苷Rg1药动学参数。结果:单独给药组和联合用药组人参皂苷Rg1的Cmax分别为1.97±0.44 mg/L、2.48±0.63 mg/L;AUC0-∞分别为8.44±2.64 mg/L·h、14.38±5.72 mg/L·h。结论:复方丹参滴丸联合氯吡格雷后,人参皂苷Rg1的Cmax和AUC0-∞增大,与二药合用协同增效相一致。

Objective： To investigate the effect of clopidogrel on the pharmacokinetic of Fufang Danshen Dripping Pill（FDDP）;Methods： 20 SD rats were randomly divided into two group,which were intrinsically administrated FDDP（324 mg/kg） alone and combination of FDDP（324 mg/kg） and clopidogrel（30 mg/kg） respectively for 21 days. The ginsenoside Rg1 from FDDP was determined by HPLC and its pharmacokinetic parameter were finally compared. Results： The value of Cmaxand AUC0-∞of ginsenoside Rg1 were increased from 1. 97 ± 0. 44 mg/L and 8. 44 ± 2. 64 mg/L·h to 2. 48 ± 0. 63 mg/L and 14. 38 ± 5. 72 mg/L ·h respectively. Conclusion： Long term with clopidogrel has effect on the pharmacokinetic character of Rg1 from FDDP,this research may provides theoretical support for the FDDP-clopidogrel combination treatment in clinical.