鞘内注射用药联合腰大池置管持续引流治疗颅内肿瘤术后颅内感染的临床效果分析

Analysis on clinical efficacy of intrathecal injection medication combining continuous lumbar catheter drainage of cisterna magna on intracranial infection of patients with intracranial tumor

目的 探究腰大池置管持续引流联合鞘内注射用药治疗颅内肿瘤术后颅内感染的临床效果。方法 回顾性分析2010年1月至2013年12月本院门诊收入的颅内肿瘤术后颅内感染50例患者的临床资料。记录并分析患者治疗前后颅内压、脑脊液中葡萄糖、蛋白质、白细胞、氯化钠含量及治疗情况。结果 50例患者治愈42例,显效3例,好转4例,无效1例,总有效率为98.0%（49/50）。治疗后颅内压及脑脊液中葡萄糖、白细胞、氯化钠、蛋白质含量较治疗前均有不同程度的变化,差异具有显著性（P〈0.05）。治疗过程中,患者静脉用药时间为8-20天,平均（12.5±2.3）天;置管引流时间为5-15天,平均（7.3±1.8）天;鞘内注射次数为5-13次,平均（6.7±1.2）次。结论 腰大池置管持续引流联合鞘内注射用药治疗颅内肿瘤术后颅内感染效果显著,可明显降低颅内压,促进患者康复,且操作简单、方便,具有较高的临床应用价值。

Objective To explore the clinical efficacy of lumbar catheter drainage of cisterna magna combining intrathecal injection medication treating intracranial infection of patients with intracranial tumor. Method Retrospective analysed the clinical data of 50 patients with intracranial infection after intracranial tumor operation in our hospital from January 2010 to December 2013. Analysed of patients before and after treatment of intracranial pressure, were the clinical indicators and treatment. Result 50 patients were cured in 42 cases, 3 cases were cured, 4 cases were improved, 1 case was ineffective, the total effective rate was 98.0%（49/50）. After treatment of intracranial pressure and CSF glucose, leukocyte, sodium chloride, protein content than the treatment index before changes in varying degrees, the difference was significant（P〈0.05）. In the course of treatment, patients in intravenous medication time was 8 - 20 days, the average was（12.5±2.3） days; catheter drainage time was 5 - 15 days, the average was（7.3±1.8） days; intrathecal injection of number was 5 - 13 times, the average was（6.7±1.2） times. Conclusion Lumbar catheter drainage of cisterna magna combining intrathecal injection of amikacin delivers significant efficacy in treating post-operative intracranial infection, it can obviously reduce intracranial pressure, promote recovery of clinical indexes, and pose simple and convenient operation, making high value of clinical service.