合成E-白藜芦醇的工业化研究

Synthesis of E-resveratrol in commercial scale production

目的研究E-白藜芦醇的工业化生产。方法以3,5-二羟基苯甲酸为起始原料,经甲基化,还原,氯代后,与亚磷酸三乙酯发生Arbuzov重排反应,再与茴香醛进行Wittig-Horner反应,最后用吡啶盐酸盐脱甲基得E-白藜芦醇。结果总收率达52.0%,纯度为98.54%。结论该合成工艺操作简便,原料易得,适于工业化生产,并通过了工业化生产验证。

Objective To study the synthesis of E-resveratrol from the view of commercial scale production. Methods The target compound was prepared from 3, 5-dihydroxy benzoic acid by methylation and reduction, followed by chloro-substituted and Arbuzov rearrangement reaction with triethyl phosphate, then condensation with anisaldehyde and demethylation with pyridine hydrochloride. Results The overall yield of this method is 52.0%. The purity of E-resveratrol is 98.54% Conclusion The improved procedure can be easily operated and is suitable for scale production. In addition, the starting materials are conveniently obtained.