碘克沙醇36例不良反应文献分析

Literature analysis of 36 cases of adverse reactions of iodixanol

目的了解碘克沙醇致不良反应的情况,促进临床合理用药。方法采用文献学计量方法,对国内公开报道的36例碘克沙醇不良反应病例进行总结性分析。结果碘克沙醇致皮肤及附件系统损害17例;全身性损害共12例,分别为迟发型全身不良反应8例、过敏性休克2例(其中1例致死亡)、严重变态反应1例、严重过敏反应1例;对比剂肾病4例;视觉损害、精神异常1例;视物模糊、剧烈头痛1例;迟发过敏反应致心脏骤停1例。结论碘克沙醇致过敏性休克、对比剂肾病、视觉损害、中枢神经系统、心血管系统等严重不良反应不容忽视。

Objective To understand the adverse reaction induced by iodixanol, to promote rational clinical drug use. Methods By means of literature metrology method, 36 cases of adverse reaction of iodixanol cases publicly reported in domestic summary analysis. Results Damage in 17 cases of skin and appendages system induced by iodixanol; Systemic damage in 12 cases, 8 cases of late onset systemic adverse reactions, 2 cases of anaphylactic shock（including 1 cases of death）, 1 cases of serious allergic reactions, 1 cases of severe allergic reaction; 4 cases of contrast induced nephropathy; 1 cases of abnormal visual impairment, mental; blurred vision, severe headache in 1 cases; delayedallergic reaction in 1 cases of cardiac arrest caused by late onset systemic adverse reactions. ConclusionIgnore the serious adverse reaction and allergic shock, contrast induced nephropathy, visual impairment, central nervous system, cardiovascularsystem induced by iodixanol.