Y染色体微缺失对卵胞浆内单精子注射胚胎发育和妊娠结局的影响

Effects of the Y Chromosome microdeletions on the embryo development and clinical outcome of the ICSI treatment cycle

目的：探讨 Y 染色体微缺失对卵胞质内单精子注射（ICSI）胚胎发育和妊娠结局的影响。方法回顾19例Y 染色体微缺失患者（研究组）进行的23个治疗周期的胚胎和临床结局资料，与同期无Y 染色体微缺失（对照组）的少弱精子症或无精子症的86个治疗周期的相应资料进行比较，分析两组患者在受精率、卵裂率、优质胚胎率、生化妊娠率、临床妊娠率、胚胎种植率、早期流产率的差异。结果研究组和对照组相比，受精率（85.0% vs 89.2%）、卵裂率（96.0% vs 95.3%）、优质胚胎率（68.3% vs 66.7%）、生化妊娠率（47.8% vs 50.0%）、临床妊娠率（43.5% vs 41.6%）、胚胎种植率（22.9% vs 20.8%）、早期流产率（10.0% vs 7.5%）差异比较无统计学意义（P＞0.05）。结论 Y染色体微缺失对胚胎质量和妊娠结局无显著性影响。

Objective To determine the effects of Y chromosome microdeletion on the embryo development and clinical outcome of the ICSI treatment cycle. Methods The embryo development and clinical outcome of 19 patients with Y microdeletions who attempted 23 ICSI cycles at our center were retrospectively analyzed in the study. The patients in study group were matched to 86 cycles at the same time who had either severe oligozoospermia or azoospermia with normal Y chromosomes （control group）. The differences between the two groups were compared including the average age, duration of infertility, the rate of natural abortion history, number of oocytes retrieved, fertilization rates、good embryo rate, number of embryos transferred, implantation rate, clinical pregnancy rate,early abortion rate. Results There were no significant differences between Groups in the rates of fertilization （85.0% vs 89.2%）, the cleavage （96.0% vs 95.3%）, good embryos （68.3% vs 66.7%）, biochemical pregnancy （47.8% vs 50.0%）, clinical pregnancy （43.5% vs 41.6%）, implantation （22.9% vs 20.8%）, and early abortion. （10.0% vs 7.5%） （P〉0.05）. Conclusion Y chromosome microdeletion has no significant effect on the embryo development and clinical outcome of the ICSI treatment cycle.