阴茎神经内分泌癌(附1例报告)

Penile neuroendocrine carcinoma(one case report)

目的：探讨阴茎神经内分泌癌（NEC）的诊断、治疗和预后。方法回顾性分析2011年我院收治的1例经病理确诊的阴茎NEC患者临床资料，并复习有关文献。结果患者行阴茎部分切除术，组织学特点和免疫组化标记物提示为原发性高分化阴茎NEC（类癌）。术后未行辅助治疗，随访24个月，无肿瘤复发。结论阴茎NEC临床罕见，组织学特点和免疫组化标记物是诊断该病的主要依据。早期手术疗效良好，术后应密切随访，预防复发和转移。

Objective To investigate diagnosis, therepy, and prognosis of penile neuroendocrine carcinoma（NEC）. Methods Clinial data of one case with NEC diagnosed by pathological examination were retrospectively analyzed ,and the relevant literatures were reviewed. Results The patient underwen partial penectomy. The findings of histopathological feature and immunohistochemisty markers supported the diagnosis of primary high differentiated penile NEC（carcinoid）. The patient did not receive adjuvant therapy due to early stage after operation.The patient had no recurrence during the two years following-up. Conclusion Penile NEC is extremely rare in clinical manifestation. Diagnosis should be depended on histological features and immunohistochemistry analysis. Early excision has a good effects, andclose follow-up after surgery is the key point to prevent recurrence and metastasis.