单纯性肥胖儿童血浆内皮素-1水平及影响因素分析

Analysis of endothelin-1 level and influence factors in simple obese children

目的 :探讨单纯性肥胖儿童血浆内皮素-1(endothelin-1,ET-1)的水平及影响因素。方法 :28例单纯性肥胖儿童为肥胖组,30例健康儿童作为对照组。放射免疫法检测血浆ET-1水平。结果:与对照组比较,单纯性肥胖儿童血浆ET-1升高,与腰围呈正相关(r=0.41,P<0.05),与高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)呈负相关(r=-0.37,P<0.05)。结论:单纯性肥胖儿童存在血管内皮功能紊乱,与血浆ET-1升高有关,后者与腰围升高及体内HDL-C水平下降有关。

Objective： To investigate plasma endothelin-1（ET-1） level and influence factors in simple obese children. Methods：28 cases of simple obese children as obesity group, and 30 healthy children as control group, the plasma ET-1 were measured by radioimmunoassay. Results： The plasma ET-1 increased in the simple obesity group compared with the control group, and positively correlated（r=0.41, P0.05） with waist circumference and negative correlation（r=-0.37, P0.05） with high density lipoprotein cholesterol（HDL-C）. Conclusion： In simple obese children, there was dysfunctions of endothelial dysfunction,associated with the increase of plasma ET-1, the later was correlated with the increase of waist circumference and the decrease of HDL-C.