环氧化酶-2检测在结直肠癌切除术后肠镜复查中的意义探讨

Significance of cyclooxygenase-2 detection in the colonoscopy review of patients with colorectal cancer after surgical resection

目的分析探讨环氧化酶-2(Cox-2)检测在结直肠癌切除术后肠镜复查中的意义。方法选择在该院接受手术切除治疗的进展期和非进展期结直肠癌患者作为研究对象,分为近期肠镜复查组(0-2年)、中期肠镜复查组(2-5年)、远期肠镜复查组(5-6年),比较各组Cox-2的m RNA、蛋白质水平及癌症复发情况。结果中期复查组及远期复查组患者的组织中Cox-2的m RNA及蛋白质水平均显著高于近期复查组(P<0.05);进展期患者Cox-2的m RNA与蛋白质水平明显高于非进展期患者。远期复查组患者的癌症复发率及息肉出现率均显著高于其他两组(P<0.05),吻合口炎症出现情况差异无显著性(P>0.05。结论结直肠癌术后患者肠镜复查间隔时间与Cox-2表达水平存在一定的相关性,且进展期患者Cox-2表达水平高,Cox-2检测可以作为是否进行肠镜复查的一个辅助指标,以达到有效监控疾病复发和节省医疗资源的目的。

【Objective】To analyze the significance of cyclooxygenase-2（Cox-2） detection in the colonoscopy review of patients with colorectal cancer after surgical resection.【Methods】Patients of advanced and non-advanced colorectal cancer received surgical resection in our hospital were selected as research objects. According to interval time for colonoscopy review, those patients were divided into the recent colonoscopy review group（0-2 years）,medium colonoscopy review group（2-5 years） and long-term colonoscopy review group（5-6 years）. Then, m RNA,protein expression level of Cox-2 and recurrence rate of colorectal cancer was compared. 【Results】In comparison with the recent colonoscopy review group, the level of m RNA, protein expression of Cox-2 in the medium colonoscopy review group and long-term colonoscopy review group were respectively statistically higher（P〈0.05）.And level of m RNA, protein expression of Cox-2 in patients of advanced colorectal cancer were statistically higher than those patients with non-advanced colorectal cancer（P〈0.05）.And the long-term colonoscopy review group had a statistically higher recurrence rate and incidence of polypus than the recent colonoscopy review group and the medium colonoscopy review group（P〈0.05）, and there was no statistically difference in the occurrence rate of anastomotic inflammation among the three groups（P〉0.05）.【 Conclusion】The interval time of colonoscopy review has a certain relevance with level of m RNA, protein expression of Cox-2 in patients with colorectal cancer after surgical resection, and level of Cox-2 expression is higher in patients with advanced colorectal cancer. So, Cox-2detection can be an auxiliary indicator for colonoscopy review to balance between controlling its recurrence and saving medical resources.