聚乙二醇散联合双歧杆菌三联活菌散治疗老年功能性便秘的临床观察

Clinical Observation of Polyethylene Glycol Combined with Bifidobacterium Triple Viable in the Treatment of Elderly Functional Constipation

目的:观察聚乙二醇散联合双歧杆菌三联活菌散治疗老年功能性便秘的临床疗效和安全性。方法:将144例老年功能性便秘患者随机均分为A、B、C组。A组患者给予双歧杆菌三联活菌散1 g,B组患者给予聚乙二醇4000散10 g,C组患者给予双歧杆菌三联活菌+聚乙二醇4000散,于早、晚餐后口服。各组患者疗程均为4周。观察各组患者的临床疗效,药物起效时间,大便形态恢复正常时间,第2、4周大便次数,治疗前后各临床症状评分及不良反应发生情况。结果:C组患者总有效率显著高于A、B组,且药物起效时间及第2、4周大便次数均显著多于A、B组,大便形态恢复正常时间显著短于A、B组,差异均有统计学意义(P<0.05)。治疗后各组患者各临床症状评分均显著低于同组治疗前,且C组低于A、B组,差异均有统计学意义(P<0.05)。各组患者治疗期间均未见严重不良反应发生。结论:聚乙二醇散联合双歧杆菌三联活菌散较单用聚乙二醇散或双歧杆菌三联活菌散疗效更为显著,安全性较好。

OBJECTIVE：To observe the clinical efficacy and safety of polyethylene glycol combined with bifidobacterium triple viable in the treatment of elderly functional constipation. METHODS：A total of 144 cases of elderly patients with functional constipation were randomly divided into group A,B and C. Group A was treated with oral administration of bifidobacterium triple viable 1 g after breakfast and dinner;group B were treated with oral administration of polyethylene glycol 4000 10 g after breakfast and dinner;group C were treated with oral administration of polyethylene glycol 4000 combined with bifidobacterium triple viable（the same usage and dosage as group A and B）. The course was 4 weeks. The clinical efficacy,drug onset time,defecation form normal time,defecation times in 2 and 4 weeks,clinical symptoms scores and adverse reactions before and after treatment were observed. RESULTS：The total effective rate of group C was significantly higher than the group A and B;the drug onset time and defecation times in 2 and 4 weeks in group C were significantly more than group A and B,the defecation form normal time was significant less than group A and B. There were significant differences（P〈0.05）. The clinical symptoms scores were significantly lower than before,and group C was lower than group A and B after treatment,with significant differences（P〈0.05）. There were no serious adverse reactions during treatment. CONCLUSIONS： Polyethylene glycol combined with bifidobacterium triple viable is more effective with good safety than polyethylene glycol or bifidobacterium triple viable alone.