63例腹膜透析相关性腹膜炎致病菌分析

Analysis on Pathogenic Bacteria of Peritoneal Dialysis-associated Peritonitis

目的探讨腹膜透析相关性腹膜炎的致病菌。方法回顾性分析63例腹膜透析相关性腹膜炎患者的临床资料,观察并分析腹透液培养的致病菌及患者转归情况。结果 63例患者中,51例患者腹透液培养阳性,阳性率高达81.0%。主要致病菌包括革兰氏阳性球菌37例,革兰氏阴性菌11例和真菌3例。3例真菌感染患者拔管后均给予抗真菌治疗,其中1例死亡,2例改用血透治疗。结论根据药敏试验结果调整抗菌药物,提高腹透液细菌培养阳性率,均有助于腹膜透析相关性腹膜炎的治疗。

OBJECTIVE To investigate the pathogenic bacteria of peritoneal dialysis-associated peritonitis （PDAP）. METHODS The clinical data of 63 patients with PDAP were retrospectively analyzed. The pathogenic bacteria cultured in extraneal and patients＇ prognosis were observed and analyzed. RESULTS The extraneal culture of 51 out of 63 patients was positive, and the positive rate came up to 81.0%. The major pathogenic bacteria included gram-positive cocci （n=37）, gram-negative bacteria （n= 11） and fungus （n=3）. Three patients with fungal infection were given antifungal therapy, in which 1 was dead and 2 were changed into hemodialysis. CONCLUSION Regulation of antibacterial agents according to the results of drug sensitive test and improvement of extraneal-cultured positive rate were conductive to the treatment of PDAP.