早期抗抑郁治疗对基底节区脑出血患者预后的影响研究

Effect of early anti-depression therapy on prognosis of patients with intracerebral hemorrhage in basal ganglia

目的探讨早期抗抑郁治疗对基底节区脑出血患者预后的影响。方法 103例患者随机分为两组。对照组给予常规治疗和护理,实验组在对照组基础上给予早期抗抑郁治疗,包括早期心理干预和抗抑郁药物治疗。采用汉密尔顿抑郁量表评分(HAMD-17)、临床神经功能缺损评分(NFA)、简式Fugl-Meyer评分(FMA)及Barthel指数BI评定,比较入院时和治疗后3个月的评分变化,评估患者抑郁状态、神经功能缺损、运动功能以及日常生活能力。结果治疗后3个月,与对照组比较,实验组HAMD评分、FMA评分、BI指数均优于对照组(P<0.01),两组NFA评分无显著差异(P>0.05)。结论早期抗抑郁治疗能够缓解基底节区脑出血患者的不良情绪,并能提高患者的预后和日常生活能力。

Objective To investigate the effect of early anti-depression therapy on the prognosis of patients with intracerebral hemorrhage in the basal ganglia .Methods 103 patients were randomly divided into 2 groups：anti-depression group and control group;routine treatment was provided to patients in both groups ,while anti-depression therapy was added to patients in anti-depression group , including early psychological intervention and anti-depression drugs;Hamilton Depression Scale （ HAMD-17 ） , Neurological Function Assessment（NFA）,Fugl-Meyer Assessment（FMA）,and Bathel Index（BI）were used to evaluated the conditions of patients in both groups and the changes of the scores at admission and 3 months after treatment were comparatively analyzed , the evaluation of depression,neurological deficits,motor function and activities of daily living was made .Results 3 months after treatment,the scores of HAMD,FMA and BI of the patients in anti-depression group were superior to those of the patients in control group （P＆lt;0.01）,while there existed no obvious statistical difference in NFA scores of patients between the 2 groups（P＆gt;0.05）.Conclusion Early anti-depression therapy can relieve the unhealthy mood of the patients with intracerebral hemorrhage in the basal ganglia and improve their prognosis and the activity of daily living .