子痫前期与血小板参数及凝血功能改变的相关性研究

Correlation Study of Pre Eclampsia and Platelet Parameters and Coagulation Function

目的检测子痫前期（PE）患者血小板参数、凝血功能指标,了解子痫前期患者凝血功能状态,判断母儿预后,为正确作出终止妊娠提供决策依据。方法收集2011年1月-2013年12月分娩的106例PE患者,随机选取120例正常足月孕妇为对照组,分娩前抽取静脉血,全自动血细胞分析仪、全自动血凝仪行相关指标分析。结果 ①重度PE组与正常妊娠组和轻度PE组相比,PLT低,MPV、PDW升高,PCT差异小;示重度PE血小板破坏后,机体产生幼稚血小板;PCT无意义;②重度PE组PT、APTT低于正常妊娠组和轻度PE组,FIB、D-D高于正常妊娠组和轻度PE组,提示血液处于高凝状态;③轻度PE组与正常妊娠组比,D-D、FIB高,MPV、PDW、PLT、PT、APTT、TT差异小,机体处于代偿;④临床上可以通过检测血小板参数和凝血功能,为PE治疗方案提供帮助。结论监测PE患者血小板和凝血功能指标的变化,有助于判断患者病情的严重程度。

Objective Preeclampsia（ PE） detection of coagulation function of platelet parameters in patients with preeclampsia,coagulation function,understanding,judging the prognosis of mothers and infants,offer the decision basis for the right to terminate pregnancy. Methods From 2011. 1to 2013. 12 in 106 cases of PE patients of our hospital childbirth,randomly selected 120 cases of normal pregnancy as control group,before the birth of venous blood,analysis of the relevant indicators of automatic blood cell analyzer,automatic blood coagulation analyzer. Results ①severe PE group and normal pregnancy group and mild compared with group PE,PLT,MPV,PDW increased,PCT difference is small;the severe PE platelet destruction,the body produces the immature platelet; PCT has no meaning; ②severe PE group PT,APTT was lower than that of normal pregnancy group and mild PE group,FIB,D- D in normal pregnancy group and mild PE group,suggesting that blood is in hypercoagulable state; ③mild PE group and normal pregnancy group,D- D,FIB,MPV,PDW,PLT,PT,APTT,TT difference is small,the body in a compensatory; ④ clinically by the platelet parameters and coagulation function test,to provide help for the PE treatment program. Conclusions Monitoring the changes of PE in platelet and coagulation function,contribute to the severity judgment patients.