2013年玉溪市人群麻疹抗体水平调查

Antibody Level of Measles in Population of Yuxi City in 2013

目的了解云南省玉溪市人群麻疹免疫状况,为制定有效的控制消除麻疹措施提供科学依据。方法采取分层和整群抽样(PPS)法进行抽样调查,应用酶联免疫吸附试验法(ELISA间接法)检测人群麻疹抗体(MVIg G)含量(m IU/ml)。结果 2013-04-30/-06-30,全市辖区内共调查3 493人,麻疹抗体阳性率为97.62%,有保护率为87.72%,麻疹抗体几何平均浓度(Geometric Mean Concentration,GMC)为2 764.49毫国际单位(m IU/ml)。区县间人群MV-Ig G阳性率、GMC差异均有统计学意义(χ2=45.27,P<0.05,F=65.86,P<0.05);各年龄段人群MV-Ig G阳性率、GMC差异也有统计学意义(χ2=122.60,P<0.05,F=17.79,P<0.05),其中<17月龄人群抗体阳性率最低为90.21%,≥18岁年龄段人群麻疹GMC相对较低,仅为1902 m IU/ml;性别间人群MV-Ig G阳性率和GMC均无统计学意义(χ2=0.02,P>0.05,F=1.69,P>0.05)。结论玉溪市人群麻疹免疫效果较好,能有效控制麻疹的暴发流行。但距实现消除麻疹目标还存在一定的差距,尤其要加强<17月龄与>14岁人群的监测工作,根据监测结果适时调整麻疹疫苗免疫策略,最终实现控制乃至消除麻疹的目标。

Objective To study the immunization status of measles in Yuxi city,Yunnan province,and to provide references for formulating effective control measures to eliminate measles.Methods With stratified and cluster sample methods,the content of MV-Ig G of the recruited individuals were tested by enzyme linked immunosorbent assay（ indirect ELISA）.Results Altogether 3493 participants were sampled in the city during Apr.30,to Jun.30,2013.The antibody rate was 97.62% and the protective rate was 87.72%.The geometric mean concentration（ GMC） was 2764.49 Miu / ml.The positive rate of MV-Ig G and GMC in counties and districts were statistically different（ χ^2= 45.27,P 0.05,F = 65.86,P 0.05）,and the differences among populations with different ages were also statistically different（ χ^2= 122.60,P 0.05,F= 17.79,P 0.05）.The positive rate in those with age less than 17 months was the lowest as 90.21%,and those with age no less than 18 years old exhibited relatively low GMC level as 1902 Miu / ml.No statistical difference was found on gender regarding the aforementioned two indicators（ χ2= 0.02,P 0.05,F =1.69,P 0.05）.Conclusion The immunization effect of measles in Yuxi city is relatively well and the out-break of measles could be effectively controlled.Nevertheless,there is distance to overcome to extinct measles,particularly the surveillance over populations of less than 17 months and over 14 years old is yet to be strengthened,and based on which immunization strate-gies should be adjusted in time.