血吸虫病肝纤维化临床血清学诊断研究进展

Research Progress in Clinical Serological Diagnosis of Liver Fibrosis Caused by Schistosomiasis

血吸虫性肝纤维化是血吸虫病发展的最后阶段,可以导致门静脉高压、腹水和上消化道出血,甚至死亡。诊断方法包括影像学、病理学和血清学诊断3种。影像学诊断在肝纤维化晚期,才能出现异常图象;病理学诊断是金标准,但存在肝穿刺的盲目性、肝脏病变的不均一性而导致取样误差;血清学诊断是应用最广泛的诊断方法。

Objective Liver fibrosis caused by schistosome is the last stage of schistosomiasis and can lead to portal hypertension,ascites and upper gastrointestinal hemorrhage,even to death.The diagnosis methods include imaging,pathological and serological examination.In imaging diagnosis,abnormal image only could be observed at advanced stage of liver fibrosis.The pathological diagnosis is the golden standard,yet its blindness in liver puncture and non-uniformity of pathological changes are the weaknesses and could cause sampling error.Serological diagnosis is the most widespread diagnosis method.