切除修复交叉互补基因1基因多态性与肺癌易感性meta分析

ERCC1 polymorphism and lung cancer risk： a meta analysis and systematic review

目的探讨切除修复交叉互补基因1（ERCC-1）rs3212986位点多态性与肺癌易感性的关系。方法使用PubMed数据库检索2013年5月以前相关文献，按纳入标准搜索研究ERC-1 rs3212986C／T多态性与肺癌易感性相关的文献，采用STATA软件进行统计分析。结果共有5009例肿瘤患者和5542名对照个体被纳入荟萃分析。分析表明ERCC-1 rs3212986C／T多态性与肺癌易感性有统计学相关性（等位基因比P=0．043，OR=0．90，95％CI：0．81-0．99）。结论ERCOI rs3212986C／T多态性与肺癌易感性存在一定的相关性，等位基因T可能会增加肺癌的易感性。

Objective To determine the association of excision repair cross completion 1 （ERCC1） rs3212986 C〉T polymorphism and lung cancer risk. Methods Pubmed database was utilized to search the literatures about association of ERCC1 rs3212986 C〉T polymorphism and lung cancer risk. All the statistical analysis was performed by STATA software. Results 5 009 lung cancer cases and 5 542 controls were included in this meta analysis. The results revealed that ERCC-1 rs3212986 polymorphism was statistically associated with lung caner risk （allelie contrast P = 0. 043, OR = 0.90,95 % CI ：0.81- 0.99）. Conclusions ERCC-1 rs3212986 polymorphism is correlated to lung cancer risk,carrying T allele may increase the risk of lung cancer.