摘要
目的:通过检测冠状动脉病变患者的血清胱抑素(cystatin C,CyC)、一氧化氮(nitric oxide,NO)及超氧化物歧化酶(superoxide dismutase,SOD)水平,探讨三者与冠状动脉粥样硬化程度的相互关系,从而评价三者对冠心病的临床诊断价值。方法经冠状动脉造影证实冠状动脉没有明显狭窄入选造影正常组,共40例;有一支血管狭窄入选单支病变组,共44例;有两支血管狭窄入选双支病变组,共43例;有大于两支血管狭窄入选多支病变组,共35例。对四组分别进行血清CyC,NO,SOD及超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平检测。结果造影正常组、单支病变组、双支病变组、多支病变组的CyC和hs-CRP水平依次呈递增趋势;NO和SOD浓度水平依次呈递减趋势,四组之间差异有统计学意义(P<0.05)。冠状动脉 Gensini积分与血清CyC和 hs-CRP水平呈正相关,相关系数分别为0.473,0.429;与NO和 SOD水平呈负相关,相关系数分别为-0.356,-0.384。血清CyC与 hs-CRP水平呈正相关,与 NO和 SOD水平呈负相关,相关系数分别为0.458,-0,426,-0.484(P<0.05)。结论随着冠状动脉病变程度的增加,CyC浓度升高,NO和 SOD减少,引起血管内皮功能障碍,导致冠状动脉发生病变及加重。CyC,NO和 SOD可作为冠心病的辅助诊断指标。
Objective To study the correlation between coronary lesion and Cystatin C (CyC),Nitric Oxide (NO)and Super oxide dismutase,accumulate the clinical experience in prevention and diagnose of Coronary Heart Disease (CHD)by analyzing the contents of serum Cystatin C (CyC),Nitric Oxide and Superoxide Dismutase in patients with coronary lesion.Meth-ods According to their severity of coronary artery lesion,all cases were divided into four groups:Normal compared group (40 cases);Simple branch pathological group (44 cases);Double branch pathological group (43 cases):Multi-branch patho-logical group (35 cases).All cases were tested CyC,NO,SOD and hs-CRP in serum.Results The level of CyC and hs-CRP were increased gradually from normal group to multi-branch group.The level of NO and SOD were decreased gradually from normal group to multi-branch group.There were significant differences the levels of CyC,NO,SOD and hs-CRP among the four groups.Coronary lesion Gensini in the CHD patients had significant positive relationship to the level of CyC or hs-CRP respectively (r=0.473,0.429),had significant negative relationship to the level of NO or SOD respectively (r=-0.356, 0.384)(P〈0.05).CyC in the CHD patients had significant positive relationship to the level of hs-CRP (r=0.458),had sig-nificant negative relationship to the level of NO or SOD respectively (r=-0.426,0.484,P〈0.05).Conclusion By aggravation of coronary artery lesion,the level of CyC increased,reduced the contents of NO,SOD,aroused endothelial dysfunc-tion,induced occurrence and aggravation of coronary artery lesion.CyC,NO and SOD play important mark in the assistant diagnosis of the disease.
出处
《现代检验医学杂志》
CAS
2015年第1期82-84,87,共4页
Journal of Modern Laboratory Medicine
基金
武汉市卫生局临床医学科研项目,编号:WX11B14.