摘要
目的:探讨高泌乳素血症患者泌乳素水平在不同时间段的变化。方法使用电化学发光法、罗氏 E170全自动免疫分析仪测定124例高泌乳素(PRL>880 uIU/ml),女性患者在7:30AM,10:00AM及4:00PM不同时间段血浆泌乳素(PRL)水平,并根据经聚乙二醇(PEG)6000沉淀巨泌乳素后的 PRL回收率分成巨泌乳素组(回收率≤40%)、单泌乳素组(回收率>60%)、可疑泌乳素组(40%<回收率≤60%),同时检测45例正常对照组的PRL水平。结果高泌乳素组巨泌乳素阳性率(33.1%)与正常对照组中巨泌乳素阳性率(0.0%)比较,差异有统计学意义(χ^2=17.8867,P<0.05),巨泌乳素组及单体泌乳素组经PEG处理前在10:00AM时间段的泌乳素浓度(1160±714 uIU/ml,885±801 uIU/ml)与7:30AM时间段的泌乳素浓度(1521±914 uIU/ml,1497±845 uIU/ml)差异均有统计学意义(t=1.993,4.46,P<0.05),巨泌乳素组及单体泌乳素组经PEG处理后在10:00AM时间段的泌乳素浓度(316±231 uIU/ml,766±611 uIU/ml)与7:30AM时间段的泌乳素浓度(488±394 uIU/ml,1235±912 uIU/ml)差异均有统计学意义(t=2.4114,3.6252,P<0.05),单泌乳素组4:00PM时间段处理前的泌乳素浓度(1033±911 uIU/ml)与7:30AM时间段处理前的泌乳素浓度(1497±845 uIU/ml)差异也有统计学意义(t=3.1686,P<0.05)。结论不同时间段泌乳素水平有变化,确定正确的采血时间,有助于临床对高泌乳素血症的诊断。
Objective To investigate prolactin(PRL)levels in patient with hyperprolactinemia in different period of time. Methods Used electrochemical luminescence method,Roche E170 automatic immune analyzer determination of detect 124 cases female patients of hyperprolactinemia (PRL〉880 uIU/ml)at 7:30AM,10:00AM and 4:00PM respectivelye of plasma PRL level,and in accordance with the polyethylene glycol (PEG)6000 precipitate PRL after A PRL recovery rate of into macroprolactin (MPRL)group (A PRL recovery rate of≤40%),single PRL group (A PRL recovery rate of〉 60%),suspicious PRL group (40%〈A PRL recovery rate of≤60%),and simultaneous detect PRL levels in 45 cases of normal control group.Results MPRL positive rate (33.1%)of high PRL group and MPRL positive rate (0%)of normal control group comparison,showed significant differences (χ^2=17.886 7,P〈0.05).MPRL group and single PRL group untreated by PEG at 10:00AM the PRL levels (1 160±714 uIU/ml,885±801 uIU/ml)and at 7:30AM the PRL levels (1 521±914 uIU/ml,1 497±845 uIU/ml)showed significantdifferences (t巨=1.993,t单=4.46,P〈0.05).MPRL group and single PRL group treated by PEG at 10:00AM of the PRL levels (316±231 uIU/ml,766±611 uIU/ml)and at 7:30AM of the PRL levels (488±394 uIU/ml,1 235±912 uIU/ml)showed significant differences (t巨=2.411 4,t单=3.625 2,P〈0.05).Single PRL group untreated by PEG at 4:00PM PRL levels (1 033±911 uIU/ml)and at 7:30AM PRL levels (1 497±845 uIU/ml)also showed significant differences (t=3.168 6,P〈0.05).Conclusion PRL levels was changed in different time.Determining the sampling time correct,conduce to the diagnosis of hyperprolactinemia clinical.
出处
《现代检验医学杂志》
CAS
2015年第1期85-87,共3页
Journal of Modern Laboratory Medicine
基金
广西壮族自治区卫生厅自筹经费科研课题(Z2009060).