纳洛酮分别联合更昔洛韦与病毒唑对病毒性脑炎患儿血清IL-1、TNF-α水平的影响比较

Affect on serum IL-1,TNF-α level of naloxone respectively combined ganciclovir and ribavirin in children with viral encephalitis

目的观察纳洛酮分别联合更昔洛韦与病毒唑治疗小儿病毒性脑炎的疗效及对血清白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)水平的影响。方法将病毒性脑炎患儿120例随机分为试验组和对照组各60例,给予所有患儿常规治疗和护理,试验组给予纳洛酮联合更昔洛韦治疗,对照组给予纳洛酮联合病毒唑治疗,治疗1周后评价2组患儿治疗效果,并于治疗前后抽取2组患儿静脉血,检测并评价血清IL-1、TNF-α水平变化。结果试验组患儿治疗总有效率为93.33%高于对照组的76.67%;治疗后2组患儿血清IL-1、TNF-α水平均呈下降趋势,但试验组降幅大于对照组,差异均有统计学意义(P<0.05)。结论纳洛酮联合更昔洛韦治疗小儿病毒性脑炎的治疗效果优于纳洛酮联合病毒唑治疗,且对血清IL-1、TNF-α水平下降幅度的影响更为显著。

Objective To observe the curative effect of naloxone respectively combined with ganciclovir and ribavirin in treatment of children with encephalitis and its effect on serum IL-1,TNF-αlevel.Methods 120 cases of patients with pedi-atric encephalitis were randomly divided into experimental group and control group ,each of 60 cases.On the basis of normal treatment and close nursing ,experience group were given naloxone combined with ganciclovir ,control group were given nalox-one combined with ribavirin .Evaluated the therapeutic effect of two groups for a week .Blood venous samples were taken of two groups before and after treatment to detect the change of serum IL-1,TNF-αlevel.Results The total effective rate of experi-ence group was 93.33% higher than 76.67% of control group;After treatment,the serum IL-1,TNF-αlevel of two groups showed a downward trend ,but the decline of experimental group was more obvious than control group ,the difference was statis-tically significant（P〈0.05）.Conclusion The curative effect of naloxone combined with ganciclovir is better than naloxone combined with ribavirin in the treatment of infantile viral encephalitis ,and the affect on serum IL-1,TNF-αlevel decline signif-icantly.