维生素D通过Wnt信号通路对肠道发育调控机制的研究进展

Research Progress of Mechanism of Vitamin D Regulating Development of the Intestine through Wnt Signaling Pathway

Wnt信号通路广泛存在于脊椎和无脊椎动物体内,对动物机体各组织器官发育,如肝脏、肾脏、肠道等起着至关重要的作用。维生素D是一组脂溶性类固醇衍生物,维生素D不直接作用于靶器官,而是通过与维生素D受体(VDR)结合从而发挥其生物学效应。近年来研究表明,VDR可以通过影响Wnt信号通路的传导进而影响肠道发育,本文就VDR对Wnt信号通路的影响、Wnt信号通路对肠道发育的调控机制等方面作一综述,以期为Wnt信号通路在肠道发育调控研究提供参考。

Wnt signaling pathway is widely present in both vertebrate and invertebrate animal’ s tissues and or-gans, it plays a very important role in many organs such as the liver, kidney and intestine. Vitamin D is a group of derivatives of fat-soluble steroid, it doesn’ t affect the target organ directly, and it works with the vita-min D receptor and exerts its biological effects. Many studies report that vitamin D receptor （ VDR） can regu-late the development of intestine through the Wnt signaling pathway. This paper reviewed the effect of VDR to Wnt signaling pathway and the Wnt signaling pathway regulating the development of intestine to make some reference for the study on regulating intestine development.