摘要
目的通过建立双侧颈总动脉结扎动物模型探讨慢性低灌注后认知功能的变化及丁苯酞的保护作用。方法雄性Wistar大鼠48只随机分为假手术组、缺血模型组、丁苯酞组。缺血组与丁苯酞组大鼠结扎双侧颈总动脉。Morris水迷宫行为学实验评估1个月后各组大鼠空间认知功能。结果慢性低灌注后1月大鼠认知功能减退,丁苯酞治疗组逃避潜伏期较缺血组明显增加,显著延长在第四象限停留时间(P<0.05)。结论丁苯酞对慢性低灌注大鼠认知功能损害有保护作用。
Objective To investigate the protective effect of butylphthalide on the cognitive function of chronic hypoperfusion rats in the bybilateral occlusion of common carotid arteries model.Methods 48 Wistar rats were randomly divided into sham group,ischemia group and butylphthalide group.The spatial cognition function of rats was evaluated with Morris Water Maze Task.Results The cognitive function of rats was reduced after chronic hypoperfusion.The escape latency and the fourth quadrant residence time of butylphthalide group were longer than these of ischemia group.Conclusion Butylphthalide has the protective effect on the cognitive function of chronic hypoperfusion rats.
出处
《中国实用神经疾病杂志》
2015年第4期34-36,共3页
Chinese Journal of Practical Nervous Diseases
关键词
慢性低灌注
丁苯酞
认知功能
Dhronic cerebral hypoperfusion
Butyphthalide
Cognitive function
