果胶凝胶在生物医学应用上的研究进展

Advances in Biomedical Applications of Pectin Gels

果胶支链多、分子量大,可被转化为水凝胶,以形成聚合物链的网状结构,使其在水中聚集起来且不溶于水。果胶由于其简单的细胞相容性胶凝机制,已被开发用于不同的生物医学应用,包括药物输送、基因传递、伤口愈合和组织工程。通过讨论果胶的结构、来源和提取程序对多糖性能的影响,从而优化凝胶的形成,得到所期望有一定应用的凝胶,建立其在医学领域中的基础性作用。

Pectin is a branched macromolecule with high molecular weight, ater. Pectin, due to its simple and cytoeompatible gelling mechanism, has been recently exploited for different biomedical applications including drug delivery, gene delivery, wound healing and tissue engineering. Pectin sources and extraction methodologies are reviewed, in view of the final properties determining the gelling mechanisms and the possible biomedical applications. Pectin structure, sources and extraction procedures have been discussed focussing on the properties of the polysaccharide that can be tuned to optimize the gels for a desired application and possess a fundamental role in application of pectin in the biomedical field.