摘要
目的研究高尿酸血症是否为新发慢性肾脏病的独立危险因素。方法通过Pub Med/Medline、Embase、SCI数据库收集了发表的关于尿酸与肾脏病的资料,共有3篇文献（包括73 123例观察对象,其中高尿酸组17 090例,正常尿酸组56 033例）按照纳入标准进入荟萃分析,通过采用Rev Man 4.2软件进行Meta分析,研究了尿酸水平升高与慢性肾脏病的关系。结果高尿酸组与正常组相比较,新发慢性肾脏病的风险提高了3.91倍（OR=3.91,95%CI：3.72~4.12）,高尿酸组具有较高的BMI,患糖尿病的人数增多。结论高尿酸血症是新发慢性肾脏病的独立危险因素,同时证实了高尿酸血症者糖尿病的患病率明显增加。
Objective To understand weather hyperuricemia is an independent risk factor of kidney disease. Methods We collected data about uric acid and kidney disease though Pub Med / Medline,EMBASE and SCI. There were three articles（ including 73123participants） taken into the meta- analysis according to inclusion criteria. And we carry on Meta analysis to these studies by using the Cochrane Collaboration’s Rev Man 4. 2 software. Results Hyperuricemia group compared with normaluricemia group,participants with hyperuricemia had a 3. 97- fold increased risk for CKD. In hyperuricemia group,observers had higher number of diabetes.Conclusion Hyperuricemia is an independent risk factor for CKD.
出处
《宁夏医学杂志》
CAS
2015年第3期229-231,共3页
Ningxia Medical Journal
关键词
尿酸
高尿酸血症
慢性肾脏病
荟萃分析
Uric acid
Hyperuricemia
Chronic kidney disease
Meta-analysis
