摘要
目的探讨浆细胞膜糖蛋白(PC-1)基因K121Q多态性与2型糖尿病合并视网膜病变的相关性。方法应用聚合酶链反应-限制性酶切片段长度多态性分析(PCR-RFLP)技术,对2型糖尿病合并视网膜病变(DR组,n=48)、2型糖尿病未合并视网膜病变(NDR组,n=56)进行PC-1基因K121Q多态性分型及研究,并与正常组(对照组组,n=56)对照分析。结果 DR组和NDR组KQ基因型频率、K等位基因频率均显著高于对照组组,差异有统计学意义(P<0.05);DR组和NDR组比较,KK型与KQ型基因型构成频率和等位基因频率差异无统计学意义(P>0.05)。结论 PC-1基因K121Q多态性与2型糖尿病相关,但其可能不是糖尿病视网膜病变发生的主要原因。
Objective To investigate the relationship between K121 Q polymorphisms of the PC- 1（ plasma cell glycoprotein-1） gene and diabetic retinopathy. Methods K121 Q polymorphism of the PC- 1 gene was analyzed by cleaved amplification polymorphism sequence- tagged sites（ PCR- RFLP）,included patients with diabetic retinopathy（ DR,n = 48）,patients without diabetic retinopathy（ NDR,n = 48） and normal controls（ con,n = 56）. Results KQ genotype frequencies and Q allele carrier frequencies in DR and NDR were obviously higher than that in con（ P 〈 0. 05）. KK and KQ genotype frequencies and allele frequencies did not reveal any statistically significant difference between DR and NDR（ P 〉 0. 05）. Conclusion K121 Q polymorphisms of the PC- 1 gene is related to T2 DM,but it isn’t associated with Diabetic retinopathy.
出处
《宁夏医学杂志》
CAS
2015年第3期246-247,共2页
Ningxia Medical Journal
基金
宁夏自然科学基金资助项目(NZ1285)
