摘要
目的了解中国人群2型糖尿病合并骨质疏松的常见危险因素。方法通过检索中国期刊网全文数据库(CNKI)、中国生物医学文献数据库搜集资料,应用Meta分析的方法对纳入文献的结果进行统计量的合并,计算标准化均数差(SMD)或加权均数差(WMD)及其95%CI。结果有26篇文献进入Meta分析,其中年龄、病程、体质量指数、糖化血红蛋白、空腹血糖、空腹胰岛素、餐后2 h胰岛素、尿白蛋白定量、碱性磷酸酶与2型糖尿病合并骨质疏松相关,但尚不能认为胰岛素敏感指数、24 h尿蛋白定量、血钙、血磷与2型糖尿病合并骨质疏松有关。结论年龄、病程、体质量指数、糖化血红蛋白、空腹血糖、空腹胰岛素、餐后2 h胰岛素、尿白蛋白定量、碱性磷酸酶是2型糖尿病合并骨质疏松的危险因素。
Objective It is to find out which risk factors are related to type 2 diabetic osteoporosis（ DOP） in China.Methods The references were retrieved through the database of CBM and CNKI,the SMD or WMD and 95% CI were calculated using meta-analysis. Results Twenty-six studies were included in which the relationship was assessed between DOP and risk factors such as age,course of disease and other relevant risk factors. The results of meta-analysis showed that DOP had a relationship with age,course of disease,BMI,glycosylated hemoglobin,fasting blood glucose,fasting insulin,postprandial 2hour insulin,quantitative of urinary albumin,alkali phosphatase level. The effect of insulin sensitivity index,quantitative of urinary protein in 24 hours,serum calcium and phosphorus between case group and control group showed no significant difference. Conclusion Age,course of disease,BMI,glycosylated hemoglobin,fasting blood glucose,fasting insulin,postprandial2 hour insulin,quantitative of urinary albumin,alkali phosphatase level are risk factors of type 2 diabetic osteoporosis.
出处
《现代中西医结合杂志》
CAS
2015年第10期1038-1040,1045,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
河北省卫生厅科研基金项目(20100278)
