糖尿病肾病患者血清8-羟基脱氧鸟苷与心脏-脚踝血管指数的关系

Association between serum 8-hydroxydeoxyguanosine and cardio-ankle vascular index in diabetic nephropathy patients

目的探讨血清8-羟基脱氧鸟苷(8-OHd G)和心脏-脚踝血管指数(CAVI)与糖尿病肾病(DN)的关系。方法随机选择60例DN患者作为DN组、70例2型糖尿病(T2DM)患者作为DM组,65例健康体检者作为正常组,测定各组受检查血清8-OHd G、24 h尿微量白蛋白水平及CAVI水平。结果 8-OHd G水平和CAVI DN组高于DM组(P均<0.05),DM组高于正常组(P均<0.05)。DN组中,大量蛋白尿组8-OHd G水平和CAVI明显高于微量蛋白尿组(P均<0.05),Hb A1c>10%组明显高于Hb A1c<9%组(P均<0.05)。结论 DN患者CAVI与血清8-OHd G相关,提示DN外周动脉硬化的进展与氧化应激有关。

Objective It is to investigate the relationship of serum 8-hydroxydeoxyguanosine（ 8-OHd G） and the cardioankle vascular index（ CAVI） in diabetic nephropathy（ DN） patients. Methods Sixty patients with DN were randomly selected as DN group,70 patients with T2 DM as DM group,65 healthy people as normal group. The levels of serum 8-OHd G,CAVI,and 24 h albuminuria were measured in each group and the results were compared. Results The levels of serum 8-Ohd G and CAVI in the DN group were higher than that in the DM group（ P 0. 05）. the levels in the DM group were higher than that in the normal control group（ P 0. 05）. In DN group,the levels of serum 8-0hd G and CAVI in the macroalbuminuria group were significantly higher than that in the macroalbuminuria group（ P 0. 05）,and the levels in the Hb A1 c 10% group were higher than that in the Hb A1 c 9 group（ P 0. 05）. Conclusion DN is related with serum 8-OHd G and CAVI,which indicates that oxidative stress play important roles in the pathogenesis of peripheral arthrosclerosis in DN.