复方苦参注射液联合GP方案治疗非小细胞肺癌临床观察

Clinical Observation of Matrine Injection Combined GP Regimen on Non-small Cell Lung Cancer

目的：观察复方苦参注射液联合GP方案治疗非小细胞肺癌（NSCLC）的疗效。方法：NSCLC患者60例,随机分为对照组和治疗组各30例。全部患者均给予GP方案治疗,治疗组患者在此基础上给予复方苦参注射液治疗,治疗1个疗程,观察并比较两组患者临床疗效。结果：两组比较,治疗组完全缓解3例,部分缓解21例,稳定3例,进展3例,总有效率80.00%（95%CI=65.69%~94.31%）,临床受益率90.00%（95%CI=73.45%~97.90%）;对照组完全缓解0例,部分缓解17例,稳定3例,进展10例,总有效率56.67%（95%CI=38.94%~74.40%）,临床受益率66.67%（95%CI=49.80%~83.54%）。两组总有效率比较差异无统计学意义（P=0.1075〉0.05）,而临床受益率比较具有统计学意义（P=0.0155〈0.05）。结论：复方苦参注射液联合GP方案治疗NSCLC效果优于单纯选用GP方案。

Objective：To observe the therapeutic efficacy of compound matrine injection combined with GP regimen on non-small cell lung cancer（NSCLC）.Methods：Sixty patients with NSCLC from January 2013 to June2014 were randomly divided into control group and treatment group（each re =30）.The patients in control group were treated with the GP regimen,while the patients in treatment group were g iven the combination regimen.After1 courses of treatment（14 days for a course）,the clinical curative effect were observed and compared between the two groups.Results：On the therapeutic efficacy,in treatment group 3 cases were complete remission,21 ones partial remission,3 ones were stable disease and 3 ones were progressive disease,the total effective rate was 80.00%（95%CI =65.69%~94.31%）,and the clinical beneficial rate was 90.00%（95%CI =73.45%-97.90%）.In control group 0 cases were complete remission,17 ones partial remission,3 ones were stable disease and 10 ones were progressive disease,the total effective rate was 56.67%（95%CI = 38.94%~ 74.40%）,and the clinical beneficial rate was 66.67%（95%CI = 49.80%~ 83.54%）.There was no statistical significance between two groups on the total effective rate（P =0.1075 〉0.05）.But there was statistical significance on the clinical beneficial rate（P =0.0155 〈0.05）.Conclusions：The therapeutic efficacy of compound matrine injection in combination with GP regimen on NSCLC is better than GP regimen.It is worth popularizing and applying.