生物可降解镁合金支架在冠状动脉血管中应用进展

Advancement of Application of Bioabsorbable Magnesium Stents in Coronary Artery

随着技术发展和实验探索,在冠状动脉介入术中,生物可降解支架有望替代金属永久性支架。应用支架是为发生血管重构和内皮愈合的早期（6～12个月）提供持续的支撑力。理想的可降解材料应具有和316 L不锈钢一样良好的力学性能,材料本身和降解产物是无毒性的,并且可以被生物体细胞和血液所吸收、利用。基于以上所涉及的特性,该文主要论述镁合金作为生物可降解材料的近期应用进展。

Biodegradable metallic stents have been investigated as alternatives for the permanent cardiovascular stents. Degradable metallic materials have been shown that the role of stenting is temporary and limited to a period of 6-12 months after implantation during which arterial remodeling and healing occur. The candidate materials for such application should have mechanical properties ideally close to those of 316 L stainless steel,and non-toxicity of the metal itself and its degraded products,and absorbable and utilized by blood and cells. Based on the mentioned requirements,here reviews the recent developments in the design and evaluation of magnesium alloy for biodegradable stents.