脐带血干细胞移植治疗肝硬化的研究进展

Research Progress on Umbilical Cord Blood Stem Cells Transplantation in the Treatment for Liver Cirrhosis

肝硬化是一种常见病、疑难病,由多种原因引起,最常见的是由慢性乙型肝炎、丙型肝炎、脂肪肝和酒精中毒发展而来。失代偿期肝硬化是各种肝纤维化疾病的终末期,平均存活时间仅为5～7年。干细胞移植已成为肝病治疗研究的热点,脐带血干细胞移植为肝硬化治疗开辟了一条新途径。该文就脐带血干细胞的特点、治疗肝硬化的理论基础、在肝硬化方面的应用、植入途径以及问题、展望等方面进行综述。

Cirrhosis is common,incurable disease,caused by a variety of reasons,the most common causes include chronichepatitis B,hepatitis C,fatty liver and alcoholism. Decompensated cirrhosisis is the endstage of various kinds of liver fibrosis,the average survival time of it is only 5 to 7 years. The research of stem cells transplantation has become one of the hot topics of treatment for liver diseases,umbilical cord blood stem cell transplantation has opened up a new way of treatment for liver cirrhosis. Here is to make a review of the characteristics of umbilical cord blood stem cell,theoretical basis of treatment for liver cirrhosis,its application in treating liver cirrhosis,the implant approach,problem and prospect,and so on.