SIRT3与线粒体适应

SIRT3 and Mitochondiral Adaptation

沉默交配型信息调节因子2同源蛋白3(SIRT3)是Sirtuins脱乙酰基酶家族中的一员,是酵母沉默信息调节因子2的同源物,是一种依赖于烟酰胺腺嘌呤二核苷酸的Ⅲ类去乙酰化酶,它调节许多线粒体的蛋白质,这些蛋白质的功能关系到代谢、氧化应激及细胞存活。SIRT3是线粒体适应性反应的调节因子,调节线粒体对应激等的适应性反应,包括代谢程序重排、加强抗氧化剂的防御机制等。另外,调控SIRT3可能是治疗线粒体功能障碍疾病的一个有希望的靶点。

Silent mating type information regulation 2 homolog 3（ SIRT3） is a member of Sirtuins family and is also a homologue of silence information regulator 2. SIRT3 is a kind of NAD＋-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism,oxidative stress,and cell survival. It is emerging as an instrumental regulator of the mitochondrial adaptive responses to stress,including metabolic reprogramming and enhancing antioxidant defense mechanisms. The manipulation of SIRT3 could be a promising target for treating some mitochondrial dysfunctional diseases.