血小板源性生长因子C和D在肾脏疾病中的研究进展

Research Progress of PDGF-C and PDGF-D in Kidney Diseases

血小板源性生长因子(PDGF)家族可调节多种病理生理活动,在肾脏中属于最典型的生长因子系统,并且越来越多的证据表明PDGF家族是多种肾脏疾病发展的关键因素。PDGF-C和PDGF-D是新发现的PDGF家族的两个亚型,与PDGF-A和PDGF-B在结构和功能上有一定差异,其在胚胎发育、恶性肿瘤、伤口愈合、动脉粥样硬化以及多个器官的纤维化中起重要作用。

The platelet-derived growth factor （ PDGF） family regulates multiple pathophysiologic events , and it belongs to the most typical growth factor systems of kidney ,and there are more and more evidence indica-ting that PDGF family is the key factor of the development of multiple renal diseases .Recently, two new mem-bers of the PDGF-family were discovered, namely PDGF-C and PDGF-D,they were different from PDGF-A and PDGF-B in structure and function.PDGF-C and PDGF-D play important roles in embryonic development, malignancy,wound healing,atherosclerosis, and fibrosis of multiple organs.