T细胞免疫与宫颈癌相关研究

Research in T Cell Immunity and Cervical Cancer

T细胞免疫与宫颈癌的发生、发展具有相关性,在宫颈癌中T细胞数量、功能、T细胞亚群比例都可能发生变化。T细胞免疫功能的发挥需要很多因素的参与,如抗原呈递细胞、细胞因子、协同共刺激分子等。高危型人乳头瘤病毒是宫颈癌的重要致病因素,也参与了T细胞免疫反应。该文重点阐述了T细胞免疫以及参与T细胞免疫的诸多因素与宫颈癌之间的关系,也涉及了宫颈癌放化疗过程中细胞免疫功能的改变。通过改善T细胞免疫功能可能有助于宫颈癌的治疗。

T cell immune,associated with the occurrence and development of cervical cancer,is subject to change in cell number,function and percentage of T cell subgroup in cervical cancer.To play the immune function,T cell needs the participation of many factors,such as antigen presenting cells,cytokines and coordi-nated stimulus molecules,etc.High-risk human papilloma virus is one of the important pathogenic factors of cervical cancer,which is also involved in the T cell immune response .Here expounds the T cell immune and relationship between various factors in the T cell response and cervical cancer ,which also involves the change of cellular immune function in the process of radiotherapy and chemotherapy of cervical cancer .It may be helpful in the treatment of cervical cancer to improve the T cell immune function .