脱氧核苷酸钠注射液预防化疗药物性肝损害及白细胞减少的临床观察

Clinical Study of Preventing Chemotherapy Drug-induced Hepatic Injury and Leucopenia with Sodium Deoxyribonucleotide Injection

目的探讨脱氧核苷酸钠注射液预防吉西他滨＋顺铂（GP）方案化疗的非小细胞肺癌药物性肝功能损害及白细胞减少的临床观察。方法选择2010年6月至2012年3月解放军第二六四医院肿瘤中心收治的非小细胞肺癌患者63例,采用随机数字表法分为观察组32例,对照组31例。两组患者均接受GP方案化疗。观察组化疗同时应用脱氧核苷酸钠注射液治疗。1个周期后对患者肝功能损害及白细胞减少等不良反应进行评价。结果观察组患者的肝功能损害的发生率显著低于对照组[28.1%（9/32）比58.1%（18/31）,P〈0.05];Ⅱ~Ⅳ度白细胞减少的发生率显著低于对照组[25.0%（8/32）比51.6%（16/31）,P〈0.05]。结论脱氧核苷酸钠注射液可有效预防化疗所致的肝功能损害及白细胞下降。

Objective To study the clinical efficacy of sodium deoxyrlhonucleotide injection in the pre- caution of drug-inducod hepatic injury and leucopenia in patients with non-small cell lung cancer（ NSCLC ） who receives GP chemotherapy. Methods A total of 63 Department of NSCLC patients admitted in the 264th Hospital of Chinese People＇s Liberation Army from Jun. 2010 to Mar. 2012 were divided into treatment group（32 cases） and control group（31 cases） according to the random number table. All the patients in the two groups were treated with GP chemotherapy, besides, patients in the treatment group were simultaneously treated with sodium deoxyribonucleotide injection. The conditions of the hepatic injury and leucopenia of the two groups were evaluated after a cycle of chemotherapy. Results In the treatment group, the incidence of hepatic injury was lower than that in the control group[ 28.1% （9/32） vs 58.1% （ 18/31 ） ,P 〈0, 05]. The incidence of leucopania（ ]I -IV ） in the treatment group was lower than that in the control group [ 25.0% （ 8/32 ） vs 51.6% （ 16/31 ） ,P 〈 0.05 ]. Conclusion Sodium deoxyribonueleotide injection can effectively prevent chemotherapy drug-induced hepatic injury and leucopenia.