降钙素原与冠状动脉粥样硬化病变程度相关性分析

Correlation between Procalcitonin and the Degree of Atherosclerotic Lesions

目的探讨降钙素原与冠状动脉粥样硬化(CAS)病变程度间的相关性。方法选择2012年1月至2014年1月仙桃市第一人民医院心血管内科收治的CAS患者100例为病例组,均行临床冠状动脉造影检查,并选择同期疑似CAS且经冠状动脉造影检查正常者100例为对照组,两组患者均在冠状动脉造影检查同时抽取静脉血进行降钙素原和高敏C反应蛋白(hs-CRP)水平检测;根据冠状动脉造影结果对病例进行分级,比较各疾病亚组之间的降钙素原和hs-CRP水平。结果与对照组比较,病例组降钙素原hs-CRP水平均显著升高[(360±69)μg/L比(50±10)μg/L,(45.59±11.25)mg/L比(1.33±0.11)mg/L,P<0.05]。随着CAS的加重,降钙素原逐渐升高;各疾病亚组间比较差异有统计学意义(P<0.05)。结论降钙素原可作为CAS分级较理想的指标,与hs-CRP联合诊断,有更高的临床应用价值。

Objective To investigate the relationship between procalcitonin and atherosclerotic lesions . Methods A total of 100 cases with coronary heart disease in Xiantao First People′s Hospital from Jan.2012 to Jan.2014 were chosen as the experimental group, and 100 cases with suspected coronary heart disease but normal coronary angiography, were chosen as control group.The serum procalcitonin and high sensitivity C reactive protein（ hs-CRP） level were detected.According to coronary angiography result, the patients were graded into different levels（ subgroups） ,and the procalcitonin and hs-CRP level of different subgroups were compared.Results The serum procalcitonin and hs-CRP level of the observation group were significantly higher than those in the control group[（360 ±69）μg/L vs （50 ±10） μg/L,（45.59 ±11.25） mg/L vs （1.33 ±0.11） mg/L,P〈0.05].The procalcitonin and hs-CRP level increased with the severity of CAS （P〈0.05）.And the differences between the different disease grades subgroups had statistical significance （P〈0.05）.Conclusion The serum procalcitonin can be used to provide a basis for the clinical grading of CAS.Combination of procalcitonin and hs-CRP can harvest higher diagnostic efficiency.