精子DNA损伤与辅助生殖研究前景

Prospect of sperm DNA damage and assisted reproductive technology research

放化疗、吸烟、辐射、睾丸和附睾的温度变化等都会造成精子DNA不同程度的损伤。目前已有多种方法可以较好地检测精子DNA的损伤程度,但是这些检测方法还有待完善。精子DNA损伤与育龄妇女的妊娠结局相关,为提高辅助生殖技术的成功率减少精子DNA损伤,可采用去除病因、中医药治疗、取睾丸精子行ICSI和IMSI等方法。鉴于此,对精子DNA损伤的原因、检测方法、妊娠结局与治疗方法作一综述。

There are multiple factors which cause sperm DNA damage,such as radiotherapy or chemotherapy, smoking, electromagnetic radiation and temperature of the testis/epididymis. Improving the methods of sperm DNA damage detection is still necessary. A number of studies have reported that sperm DNA damage is associated with reproductive outcome. For the sake of succeeding in ART and the reducing of sperm DNA damage, some treatments are taken into consideration, such as exterminating the causes, oral antioxidant drugs, traditional Chinese medicine and ICSI /IMSI with testis sperm. This review focuses on the mechanism and detection of sperm DNA damage, it＇s association with reproductive outcomes, and relevant treatment strategies in assisted reproductive technology.