氟伏沙明联合氯米帕明治疗青少年强迫症效果观察

Observation of fluvoxamine combined with clomipramine in treatment of adolescent obsessive compulsive disorder

目的探讨氟伏沙明联合氯米帕明治疗青少年期强迫症临床效果。方法对我院收治的90例患者资料进行分析,将其随机分为两组,对照组采用氟伏沙明治疗,观察组联合氯米帕明治疗,比较两组治疗效果。结果观察组总有效率高达80%,明显高于对照组的60%,差异有统计学意义(P<0.05);观察组治疗后Yale-Brown强迫量表评分为(9.01±3.12)分、汉密顿抑郁评分为(4.72±2.03)分、汉密顿焦虑量表评分为(4.92±1.83)分,均低于对照组(P<0.05);两组强迫思维、强迫动作差异无统计学意义(P>0.05);观察组不良反应发生率为40%,低于对照组的70%(P<0.05)。结论氟伏沙明联合氯米帕明治疗青少年强迫症效果理想,值得推广应用。

Objective To investigate the clinical effect of fluvoxamine combined with clomipramine in the treatment of adolescent obsessive compulsive disorder. Methods The data of 90 patients in our hospital were analyzed, they were randomly divided into two groups, the control group using fluvoxamine treatment, the observation group combined with clomipramine, the treatment effect of the two groups were compared. Results The total effective rate of the observation group was up to 80%, higher than that of the control group（60%）, with statistical significance（P〈0.05）; After treatment, Yale-Brown Obsessive Compulsive Scale score of observation group was（9.01±3.12）, Hamilton depression score of（4.72±2.03）, Hamilton Anxiety Scale score of（4.92± 1.83）, were lower than the control group（P〈0.05）; The obsession,compulsion of two groups was not significant difference（P〉0.05）; the observation group the incidence of adverse reaction was 40%, lower than the the control group（70%）（P〈 0.05）. Conclusion The treatment effect of fluvoxamine combined with clomipramine in treatment of adolescent obsessive compulsive disorder is ideal, worthy of popularization.