小牛血清去蛋白注射液与6种输液配伍的稳定性考察

目的考察小牛血清去蛋白注射液与6种临床常用输液配伍的稳定性，为临床使用提供参考。方法模拟临床用药浓度，将小牛血清去蛋白注射液20mL分别加入250ml0．9％氯化钠注射液（0．9％NS）、5％葡萄糖注射液（5％GS）、10％葡萄糖注射液（10％GS）、5％葡萄糖氯化钠注射液（5％GNS）、果糖注射液和转化糖注射液中，依次在0、1、2、4、6h时间点。采用外观观察法、pH检测法、不溶性微粒检查法、紫外-可见分光光度法、无菌检查法，比较小牛血清去蛋白注射液与6种输液配伍后的外观、pH、不溶性微粒、紫外吸收光谱的变化，以及无菌检查是否合格。结果6种配伍液在各时间点，外观、pH值、紫外吸收光谱均无显著变化，且无菌检查合格，但不溶性微粒明显增多。结论小牛血清去蛋白注射液可以与上述6种输液配伍，在6h内较稳定，但配伍后不溶性微粒明显增多。因此，在临床应用中应重视加强配伍后不溶性微粒的监测，尽量避免不良反应发生，确保临床用药安全。

Objective To observe the stability of infusion compatibility between the deproteinized calf blood serum injection and six kinds of infusion solutions, and to provide the clinical reference of using drug. Methods By simulating the clinical concentration, deproteinized calf blood serum injection was respectively added to 0.9% sodium chloride injection, 5% glucose injection, 10% glucose injection, 5% glucose and sodium chloride injection, fructose injection and invert sugar injection, the appearance, pH, insoluble particules, UV absorption spectrum and sterility test at different time intervals were observed. Results The appearance, pH and UV absorption spectrum were all stable in 6 infusion solutions, and sterility test is qualified, but the numbers of insoluble particules of different diameters were obviously increased. Conclusion Deproteinized calf blood serum injection can be mixed in these six infusion solutions, and was stable within 6 hours, but the increase of insoluble particules in infusion solutions may be focused and monitored during clinical use, so the adverse reactions can avoid as far as possible, and the drug of clinical use can be safe.