一种新型手性配体SPAN-BiSO的合成

Synthesis of a Novel Chiral Ligand SPAN-BiSO

以对甲基苯酚和丙酮为原料,经过缩合、溴化和硫化反应合成了一个新型的手性双亚砜配体——SPANBi SO{8,8'-二-(R)-叔丁基-4,4,4',4',6,6'-六甲基-2,2'-螺二[色满](3)};3经柱层析纯化得两个非对映异构体(3a和3b),其纯度(HPLC)大于99%。3a和3b的结构经1H NMR,13C NMR和HR-MS表征。

A novel ehiral ligand, 8,8＇-bis-（R） -tert-butylsulfinyl） -4,4,4,4＇,6,6＇-hexamethyl-2,2＇-spi- robi[ chromane] （3）, was synthesized from p-methyl phenol and acetone by a three-step of condensa- tion, bromide and sulfuration. 3 was purified by column chromatography to give two diastereomeric iso- mers（3a and 3b）. Pufity（HPLC） of 3a and 3b is greater than 99% and the structures were character- ized by 1H NMR, 13C NMR and HR-MS.