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环氧化酶2及癌胚抗原在结肠癌分子病理研究中的作用研究 被引量:1

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摘要 目的研究环氧化酶2(COX-2)及癌胚抗原(CEA)在结肠癌分子病理研究中的作用。方法随机选取2010年5月至2012年7月我院收治的46例结肠癌根治术患者的组织标本作为研究对象,同时收集新鲜结肠癌组织远、近端癌旁1、2、3 cm的肠壁组织以及与肿瘤相距约8 cm正常肠壁组织,采用RT-PCR技术检测环氧化酶2(COX-2)及癌胚抗原(CEA)与上述组织之间的表达情况。结果 46例患者中肿瘤远、近端3 cm处肠壁病理切缘均呈现阴性;近端癌旁1、2、3 cm肠壁组织以及到距离肿瘤8 cm正常结肠组织之间具有递减趋势;近端、远端3 cm处CEAm RNA与COX-2m REA并没有肿瘤组织表达的明显,差异显著,具有统计学意义(P<0.05);同比正常组织,差异不明显,无统计学意义(P>0.05)。结论临床可选择COX-2、CEA作为结肠癌分子边缘研究的分子标志物,二者具有一定的研究价值。
出处 《中国医药指南》 2015年第7期131-132,共2页 Guide of China Medicine
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  • 1Jia-Li Liu, Zhen-Ning Wang, Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China Yuan Liang, Department of Oncology, the Shengjing Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China Xin Zhou, Department of Obstetrics and Gynecology, the Shengjing Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China Li-Li Xing, Department of Oncology, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China.Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis[J].World Journal of Gastroenterology,2010,16(43):5510-5517. 被引量:5
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