丹红注射液合并硝酸甘油对急性心肌梗死患者PCI治疗中无复流现象及C-反应蛋白的影响

Effect of Dan Hong Injection Combined with Nitroglycerin on No-Reflow and CRPin PCI Treatment for AMI Patients

目的:研究急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)前静脉注射丹红注射液对术中无复流血流的改善及C-反应蛋白(CRP)的影响。方法:对120例AMI患者术前均给予阿司匹林300 mg、氯吡格雷300 mg等治疗。随机分成A组与B组两组,各60例。A组PCI术前予以丹红注射液,术中出现无复流2例,再予以硝酸甘油冠脉内给药;B组直接行PCI术,术中出现无复流8例,再予以硝酸甘油冠脉内给药,对比两组患者冠脉血流恢复情况。同时两组患者均在术前及术后监测CRP。结果:A组全部冠脉血流恢复TIMI3级,B组有4例冠脉血流恢复TIMI3级,且用丹红注射液组术后CRP降低更明显。结论:PCI术前静脉注射丹红注射液可以降低AMI患者的CRP值,且联合硝酸甘油后较单一给予硝酸甘油可更有效恢复无复流血管的TIMI血流值。

Objective： to study the effect of Dan Hong injection on no-reflow improvement and CRP of AMI patients prior to PCI therapy. Methods： 120 AMI patients,treated with Aspirin 300 mg and Clopidogrel 300 mg before operation,were randomly divided into group A and B,60 cases each. Group A were given Dan Hong injection before PCI,two cases shown no reflow in operation,and then administered with nitroglycerin into coronary artery; group B were given PCI directly with 8 cases of no reflow,which was followed by nitroglycerin into coronary artery. Compare the blood flows between the two groups and observe CRP changes of both groups before and after operation. Results： All blood flows of group A recovered to TIMI3 level,while only 4 cases in group B recovered to the same level. In addition,CRP of group A decreased significantly after operation. Conclusion： prior to PCI,intravenous injection of Dan Hong can decrease CRP,and the combination with nitroglycerin can recover more effectively the TIMI flow value of no reflow vessel than nitroglycerin only.