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2-氨基-3-硝基-6-(4-氟苄基氨基)吡啶(ANFP)合成研究

Study on Synthesis of N6-[(4-fluorophenyl)methyl]-3-nitropyridine-2,6-diamine(ANFP)
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摘要 以2,6-二氯-3-硝基吡啶为起始原料,在合成2-氨基-3-硝基-6-氯吡啶(AFP)时,反应时间在10 h、反应温度在26℃时原料反应最完全;用AFP合成2-氨基-3-硝基-6-(4-氟苄基氨基)吡啶(ANFP)时,用10倍水、1.2倍对氟苄胺、1.1倍三乙胺,原料反应最完全,同时又能保证溶剂的绿色化减少污染. The starting material 2, 6-dichloro-3-nitropyridine in the synthesis of 2-amino-6-chloro-3-nitropyridine （AFP）, can complete conversion on reaction time 10 h, the reaction temperature 26 ℃ ; When synthesized N6-[ （4- fluorophenyl） methyl]-3-nitropyridine-2, 6-diamine （ANFP） by AFP, with 10 times of water, 1.2 times for 4- fluorobenzylamine, 1.1 times triethylamine, material can complete conversion, at the same time, maintaining the green solvent to reduce pollution.
作者 王新灵 李海超 孙德梅 杨静
机构地区 河南中医学院药学院 郑州拓康科技有限公司
出处 《河南科学》 2015年第3期350-352,共3页 Henan Science
基金 河南中医学院博士基金项目(BSJJ2010-26)
关键词 2-氨基-3-硝基-6-(4-氟苄基氨基)吡啶(ANFP) 合成 N6-[ （4-fluorophenyl）methyl]-3-nitropyridine-2, 6-diamine（ANFP） synthesis
分类号 R971.1 [医药卫生—药品]
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参考文献9

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