腹腔置管引流联合5-FU加香菇多糖治疗癌性腹水

Abdominal Indwelling Catheter Drainage Combined with 5-FU and Mushrooms Polysaccharides in the Treatment of Malignant Ascites

目的:探讨腹腔置管腹水引流联合腹腔内灌注药物治疗恶性腹水的疗效。方法:对40例晚期恶性腹水患者采用静脉置管术,将中心静脉导管置于腹腔内,引流腹水后经导管灌注5-FU加香菇多糖。结果:40例患者完全缓解18例,部分缓解12例,有效率为75%。毒副反应轻,主要为轻度消化道反应和一过性腹痛。结论:对于晚期癌症合并大量腹水患者,腹腔置管引流、腔内灌注5-FU加香菇多糖,方法简单,易于操作,给药副作用低,药物利用率高,能够减轻患者痛苦,提高生活质量,延长存活期。

Objective： To investigate the efficacy of abdominal indwelling catheter drainage combined with intraperitoneal ascites drug peffusion in the treatment of malignant ascites.Method： 40 cases with advanced malignant ascites used vein catheterization, the central venous catheter placed in the abdominal cavity, drainage of ascites after catheter perfusion 5-FU and Mushrooms Polysaceharide.Result： The complete remission was 18 cases in 40 cases, partial remission was 12 cases, efficiency was 75%.Mild adverse reaction was mainly mild gastrointestinal reaction and transient abdominal pain. Conclusion： For advanced cancer patients with massive ascites, peritoneal drainage, intravesical instillation of 5-FU and Mushrooms Polysaccharide are simple, easy accessibility, administration of low side effect, high utilization ratio of drug, to alleviate the suffering of patients, enhance the quality of life, prolong the survival period.