土豆片外敷治疗静脉输液外渗的动物实验研究

Animal experimental study on potato chips external applying to treat intravenous infusion extravasation

[目的]建立大鼠水肿动物模型并探索土豆片外敷治疗静脉输液外渗的机制。[方法]选取大鼠后足背部位进行皮下注射20%甘露醇0.25mL,注射药物10min后,采用自身对照实验,左右足背部分别为对照组和实验组,实验组采用土豆片外敷,对照组隔两层塑料薄膜后再敷土豆片。每隔2h更换1次土豆片,共干预8h,并每2h拍照观察局部变化并用量尺测量水肿局部的长、宽和高。[结果]该水肿模型应用土豆片干预后,大鼠局部皮肤肿胀消退,且实验组消退程度大于对照组(P<0.05)。[结论]通过大鼠足背部皮下注射20%甘露醇成功建立大鼠水肿模型,新鲜土豆片具有消肿作用。

Objective：To establish the model of edema in rats and to explore the mechanism of potato chips ex-ternal on treatment of intravenous infusion extravasation.Methods：To selected foot dorsal parts of rat,to give subcutaneous injection of 20% mannitol 0.25 mL.After 10 min,using self control experiment,left and right foot dorsal part respectively as the control group and the experimental group.The experimental group adopted potato chips external applying.The left foot dorsal parts of control group were covered with two layers of plastic films and then applied with potato chips.Every 2 h change potato chips for 8 h intervention.And every 2 h pho-tographs were taken and local changes were observed.And edema local length,width and height were measured by measure gage.Results：After application of potato slices intervention on the edema model,rat local skin swelling subsided.And the experimental group depletion degree was greater than the control group（P 〈0.05）. Conclusion：By subcutaneous injecting of 20% mannitol in rat foot back successfully,a rat model of edema has been established.Fresh potato chips have detumescence effect.