加味四逆散治疗肝胃不和型慢性浅表性胃炎的临床疗效观察

Clinical Efficacy of Jiaweisinisan on Chronic Superficial Gastritis with Liver-stomach Disharmony: A Clinical Observation

目的:观察加味四逆散治疗肝胃不和型慢性浅表性胃炎的临床疗效。方法:采用随机、开放性、对照的临床试验设计,将60例肝胃不和型慢性浅表性胃炎的患者按1:1的比例随机分为治疗组与对照组。治疗组予加味四逆散治疗,对照组予以奥美拉唑肠溶胶囊和多潘立酮片,疗程为4周,观察两组患者治疗前后证候的变化,并追踪复发情况。结果:总有效率治疗组为96.7%,对照组为90.0%,两组比较,差异无统计学意义(P>0.05);疗程结束后1月随访,治疗组复发率为3.5%,对照组复发率为25.9%,治疗组低于对照组(P<0.01)。结论:加味四逆散治疗肝胃不和型慢性浅表性胃炎疗效确切,在改善症状及减少复发方面效果显著。

Objective： To observe the clinical effect of Jiaweisinisan （加味四逆散） on Chronic superticlal gastritis with hv- er-stomach disharmony. Methods： A randomized, open and controlled clinical trial design was applied; According to the ratio of 1：I, the 60 cases of patients with Chronic superficial gastritis with liver-stomach disharmony were randomly divided into treatment and control groups. Patients were treated by Jiaweisinisan in treatment group and Omeprazole Enteric-coated Cap- sules plus Domperidone Tablets in control groups and the treatment cours was 4 weeks. The change of syndrome was ob- served, as well as the recurrence. Results： The total effective rate was 96.7% in treatment group and 90.0% in control group, and there was no statistical difference （P〉0.05）; the recurrence rate was 3.5% in treatment group and 25.9% in control group a month, and the treatment group showed lower recurrence than the control group （P〈0.01）. Conclusion： Jiaweisinisan can provide curative effect for Chronic superficial gastritis, relieve symptom and reduce the recurrence.