急性缺血性脑卒中患者血浆Lp-PLA2水平与神经功能缺损程度的相关性研究

Correlation of Lp-PLA2 levels and neurological function deficits of patients with acute ischemic stroke

目的探讨急性缺血性脑卒中患者血浆Lp-PLA2水平与神经功能缺损程度的关系。方法选取92例急性缺血性脑卒中患者作为观察组,80例健康人为对照组,比较2组患者的Lp-PLA2水平与脑梗死体积、神经功能缺损程度的关系。结果急性缺血性脑卒中患者血浆Lp-PLA2水平高于健康人,差异有统计学意义(P<0.05);随着脑梗死体积增大和神经功能缺损程度加重,血浆Lp-PLA2水平呈增高的趋势;Spearman相关分析显示:血浆Lp-PLA2水平与NIHSS评分呈正相关。结论 Lp-PLA2与缺血性脑卒中患者的神经功能缺损程度呈正相关。

Objective To investigate the correlation of Lp-PLA2 levels and neurological function deficits of patients with acute ischemic stroke. Methods Totally 92 patients with acute ischemic stroke were considered as observation group and 80 healthy people were considered as the control group. The relationships between Lp-PLA2 levels and neurological function deficits and infarction volume were compared. Results Lp-PLA2 level of observation group was higher than that of control group, which had statistical difference （P〈0.05）; The serum Lp-PLA2 level was gradually increasing with the cerebral volume increasing and neurological function deficits aggravation; Spearman correlation analysis showed the levels of Lp-PLA2 were positively correlated with NIHSS scores. Conclusion The serum Lp-PLA2 level of patients with acute ischemic stroke is positive correlated with the neurological function deficits.