多发性硬化的临床特点分析

Clinical characteristic analysis of patients with multiple sclerosis

目的探讨多发性硬化(MS)的临床表现特点。方法回顾性分析2007-01—2010-06于我院确诊的68例多发性硬化病例,总结其一般资料、临床表现、病变部位、重要辅助检查及治疗转归等。结果 68例患者中,首发症状以肢体无力(28例,41.2%)最常见;肢体无力、感觉障碍、视觉损害是MS患者最常见的症状;MS好发于青壮年,以急性和亚急性起病为主;视、听、体感诱发电位(VEP、BAEP、SEP)有助于发现亚临床病变;脑脊液(CSF)检查可有异常;磁共振(MRI)检查阳性率高;临床定位以大脑半球、脊髓和视神经受累最多见。糖皮质激素及免疫球蛋白治疗有效。结论根据临床特点,结合神经电生理脑脊液及影像学等检查能大大提高MS的临床确诊率。

Objective To investigate the clinical characteristic analysis of patients with multiple sclerosis （MS）. Methods The data of 68 patients with MS in our hospital from January 2007 to June 2010 were retrospectively analyzed. The general in- formation, clinical manifestation, lesion locations, important auxilianry examinations and treatment outcomes of patients were summarized. Results Among 68 cases of patients with MS, the first symptom was limb weakness （28 cases, 41.2%） and the most common symptom was limb weakness, paraesthesia and visual impairment. MS mainly occurred in young adults with acute and subacute onset. The VEP, BAEP and SEP helped to find subclinical lesions. There were abnormal CSF and MRI. The most common clinical orientation of MS was in cerebral hemisphere, spinal cord and optic nerve involvement. Corticosteroids and immunoglobulin could effectively treat patients with MS. Conclusion The clinical diagnosis rate of patients with MS was significantly increased by clinical manifestations with neuroelectrophysiotogy, cerebrospinal fluid examination and magnetic resonance imaging.