急性脑梗死患者高敏性C反应蛋白与临床预后的关系

Relationship between high sensitivity C-reactive protein and clinical prognosis in patients with acute cerebral infarction

目的探讨高敏性C反应蛋白(hs-CRP)与急性脑梗死患者临床预后的关系。方法选取973例症状发作24h后诊断为急性脑梗死患者,在入院当天和第7天检测血液hs-CRP浓度,随访12个月探讨hs-CRP与临床预后的关系。结果入院当天和第7天hs-CRP浓度与脑梗死后12个月改良的Rankin分级(mRS)评分明显相关,mRS评分与第7天hs-CRP浓度较入院当天hs-CRP浓度关系更密切。结论脑梗死后第7天hs-CRP浓度明显高于发病24h内,提示hs-CRP对临床预后有明显的预测作用,是急性卒中有用的标志物。

Objective To investigate the relationship between high sensitivity C-reactive protein and clinical prognosis in patients with acute cerebral infarction. Methods The hs-CRP levels of 973 patients with acute cerebral infarction were detected on admission and on the seventh day and then followed up 12 months after stroke onset to investigate the correlations between hs-CRP level and clinical prognosis. Results There were obvious correlations between the hs-CRP level on admission and on the seventh day and the modified Rankin scale （mRS） score at 12 months after cerebral infarction. The mRS scores were more closely associated with hs-CRP levels on the seventh hospital day than hs-CRP levels on admission. Conclusion The hs-CRP level on the seventh day after cerebral infarction is higher than that on admission. This result suggests that hs-CRP can predict the clinical prognosis of stroke patients and is a useful marker of acute stroke.