西咪替丁对过敏性紫癜患儿心率、QT间期及心率校正的QT间期的影响

Effect of cimetidine on heart rate,QT interval and linear corrected QT of children with allergic purpura

目的观察西咪替丁佐治小儿过敏性紫癜对心率及QT间期、心率校正的QT间期(linear corrected QT,QTLc)的影响并探讨其临床意义。方法采用随机对照的研究方法,选择腹型过敏性紫癜患儿83例,随机分为观察组和对照组。对照组37例,给予地塞米松、维生素C、钙剂综合治疗;观察组46例,在综合治疗基础上加用西咪替丁。观测心电图心率及QT间期、QTLc情况。结果用药后心率及QT间期、QTLc两组间比较差异有统计学意义,在综合治疗的基础上加用西咪替丁的观察组较对照组心率减慢,QT间期及QTLc延长。结论临床小儿使用西咪替丁治疗期间须监测心电图心率及QT间期、QTLc变化,避免室性心律失常的发生。

Objective To observe the effect of cimetidine on the heart rate, QT interval and linear corrected QT （QTLc） of children with allergic purpura. Methods Randomized controlled trial was conducted in this study. A total of 83 children with abdominal allergic purpura were randomly divided into two groups： control group （n = 37） and observation group （n = 46）. All patients received combined modality therapy with dexamethasone, vitamin C and calcium supplements, while patients in the observation group were given cimetidine additionally. Heart rate, QT interval and QTLc were monitored during the treatment. Results There were statistical significance in heart rate, QT interval and QTLc between two groups. Compared with the control group, the heart rate in observation group decreased,but QT interval and QTLc prolonged. Conclusion During the treatment with eimetidine for the children with allergic purpura, heart rate, QT interval and QTLc should he monitored in order to avoid ventricular arrhythmia.